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The physical specs of the 2TB hard drive seem compatible: 2TB 5400 RPM 32MB Cache SATA 6.0Gb/s 2.5" 9.5mm high. Is there any incompatibility other than physical that would prevent from upgrading with that hard drive? Thanks. Fred.

Any 2.5" SATA drive should work fine. One standard trick to get a speed bump is to replace the current internal hard drive with: a faster RPM drive (replacing a 5400 drive with a 7200 drive, for example)a hybrid drive (a traditional hard drive with a large cache)a solid-state SSD drive You can then take your larger traditional hard drive and swap it into the optical drive bay with an appropriate mounting bracket. This gives you the speed advantage of the faster boot drive, with the storage space of a traditional hard drive. Unibody Laptop Dual Drive

As far as I know, you shouldnt get problems as long as your SSD/HDD has a capacity of less than 2.19 TB ! I suggest reading http://www.wdc.com/wdproducts/library/Wh… yourself … … limitations of 512-byte Sector Size may prefent you from using drives with higher capacity and there might be problems with capacities of more than 4TB, HFS+ should support volume sizes of up to 80000000 TB = 8 exabyte ( https://en.wikipedia.org/wiki/HFS_Plus )